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US 11,505,551 B2Granted
Methods for preparing substituted pyridinone-containing tricyclic compounds
AssigneeArbutus Biopharma Corporation
InventorsShuai Chen, Bruce D. Dorsey, Dimitar B. Gotchev, Duyan Nguyen, Mahesh Kumar Pallerla, Ganapati Reddy Pamulapati
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Abstract
The present disclosure relates to novel, scalable methods of making substituted tricyclic compounds that are useful to treat and/or prevent HBV and/or HBV-HDV infection and related conditions in a subject.
Claims31
A method of preparing (S)-6-isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro-6H-pyrido[1,2-h][1,7]naphthyridine-9-carboxylic acid
- or a salt or solvate thereof, the method comprising hydrolyzing (S)-6-isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro-6H-pyrido[1,2-h] [1,7]naphthyridine-9-carboxylic ester
- or a salt or solvate thereof, wherein R is C1-C6 alkyl, C3-C8 cycloalkyl, or benzyl.
Dependencies are inferred from the claim text.