Biocompatible surfaces and devices incorporating such surfaces
AssigneeW. L. Gore & Associates, Inc.
InventorsKeith A. Knisley, Vishnu T. Marla, Rachel Radspinner, Paul A. Silvagni, Jason J. Strid, Michael J. Vonesh
Life of this patent
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Abstract
The invention is an improved biocompatible surface for a variety of medical purposes. The biocompatible surface employs a unique tight microstructure that demonstrates enhanced cellular response in the body, particularly when placed in contact with blood. As a blood contact surface, the present invention can be beneficially employed in a wide variety of implantable devices and in many other devices and equipment that come in contact with blood.
Claims19
A blood contact surface comprising:
- a synthetic biomaterial having a microstructure of interconnected fibrils morphologically analogous to microstructure of a natural human fibrin mat, wherein the synthetic material comprises a fluoropolymer, and wherein the fluoropolymer is expanded and comprises fibrils and nodes with an average internodal distance of less than about 5 microns.
A blood contact surface comprising
- a fluoropolymer having a node and fibril microstructure substantially as shown in FIG. 4.
A blood contact surface comprising
- a fluoropolymer having a node and fibril microstructure morphology substantially as shown in FIG. 5.
A blood contact surface comprising
- a fluoropolymer having a node and fibril microstructure morphology substantially as shown in FIG. 22.
An implantable medical device that comprises a blood contact surface of a synthetic biomaterial having a microstructure of interconnected fibrils morphologically analogous to microstructure of a natural human fibrin mat, wherein the synthetic material comprises a fluoropolymer, and wherein the fluoropolymer is expanded and comprises fibrils and nodes with an average internodal distance of less than about 5 microns.
A blood contact surface that comprises a synthetic biomaterial having a microstructure of interconnected fibrils morphologically analogous to microstructure of a natural human fibrin mat, said blood contact surface comprising an implantable vascular graft, wherein the synthetic biomaterial comprises a fluoropolymer, and wherein the fluoropolymer is expanded and comprises fibrils and nodes with an average internodal distance of less than about 5 microns.
A blood contact surface of a synthetic biomaterial having a microstructure of interconnected fibrils morphologically analogous to microstructure of a natural human fibrin mat, said blood contact surface comprising an implantable stent-graft, wherein the synthetic biomaterial comprises a fluoropolymer, and wherein the fluoropolymer is expanded and comprises fibrils and nodes with an average internodal distance of less than about 5 microns.
A blood contact surface of a synthetic biomaterial having a microstructure of interconnected fibrils morphologically analogous to microstructure of a natural human fibrin mat;
- wherein the microstructure has an internodal distance in a first x direction that is approximately the same as an internodal distance in a perpendicular y direction.
A blood contact surface of a synthetic biomaterial having a microstructure of interconnected fibrils morphologically analogous to microstructure of a natural human fibrin mat;
- wherein the microstructure has an internodal distance in a first x direction and an internodal distance in a perpendicular y direction;
- and
- wherein a ratio of internodal distances in the x and y directions comprises about 1:1.
Dependencies are inferred from the claim text.