Attenuated virus strain and use thereof as a vaccine
AssigneesUniversite Claude Bernard Lyon 1, Centre National de la Recherche Scientifique (CNRS), Ecole Normale Superieure De Lyon, Institut National De La Sante Et De La Recherche Medicale (Inserm), Universite Laval
InventorsManuel Rosa-Calatrava, Guy Boivin, Julia Dubois, Mario Andres Pizzorno, Olivier Terrier, Marie-Eve Hamelin, Marie-Helene Cavanagh
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Abstract
The present invention relates to an attenuated virus strain derived from a human metapneumovirus strain comprising the genome sequence represented by sequence SEQ ID NO. 1, said attenuated strain comprising one or more genetic modifications of said sequence SEQ ID NO. 1 attenuating the virulence of said strain.
Claims10
An attenuated human metapneumovirus strain comprising one or more genetic modifications of sequence SEQ ID NO. 1 attenuating the virulence of said strain, wherein the genetic modifications of said sequence SEQ ID NO.1 consist of the inactivation of the gene encoding for the SH protein and/or the inactivation of the gene encoding for the G protein.
Dependencies are inferred from the claim text.