Bacterial inhibitors
OwnerHua Xie, Richard J. Lamontinventors
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Abstract
Peptides related to certain portions of the arginine deiminase enzyme from the bacterium Streptococcus cristatus are provided that disrupt the formation and composition of biofilms containing the oral pathogen Porphyromonas gingivalis, and also modulate the virulence of P. gingivalis. Pharmaceutical compositions containing such peptides and method of using the same are disclosed.
Claims20
A method of treating a biofilm comprising Porphyromonas gingivalis, the method comprising administering to a subject a therapeutically effective amount of a compound comprising a peptide consisting of the sequence of SEQ ID NO:
- 6, wherein the peptide has no arginine deiminase activity.
A method of treating a biofilm comprising Porphyromonas gingivalis in a subject, the method comprising administering to the mouth of the subject a compound comprising a peptide consisting of the sequence of SEQ ID NO:
- 6, wherein the peptide has no arginine deiminase activity.
Dependencies are inferred from the claim text.