# US 11,499,949 B2 · Heaters and their use in temperature gradient and traveling wave chromatography > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,499,949 B2 - Document ID: US11499949B2 - Status: Granted - Kind: B2 - Application number: 16/733,026 - Filed: 2020-01-02 - Published: 2021-07-08 - Granted: 2022-11-15 - Earliest claimed: 2020-01-02 - Assignees: PerkinElmer Health Sciences, Inc. - Applicants: Perkinelmer Health Sciences, Inc. - Inventors: Samuel Tolley; Chad Kingston - Web page: https://patentgrep.com/patent/US11499949B2 ## CPC - G01N 30/64: Electrical detectors - G01N 30/30: of temperature - G01N 2030/0095: {Separation specially adapted for use outside laboratory, e.g. field sampling, portable equipments} - G01N 2030/025: {Gas chromatography} - G01N 2030/3015: {temperature gradients along column} - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) ## Abstract Certain configurations are described of column heaters that can be used in gas chromatography applications to provide individual heating zones along a gas chromatography column. The column heater may comprise a plurality of inductive elements that can be used to provide heating zones. A thermally conductive support can be used with the gas chromatography column and the inductive elements if desired. The column heater can be used to provide a travelling wave, a thermal gradient or other heating profiles. ## Claims ### Claim 1 A heater comprising a plurality of individual inductive heaters, each individual inductive heater comprising an inductive element and an aperture configured to receive a gas chromatography column, each inductive element comprising a plane being arranged substantially parallel to a plane of each of the other inductive elements, wherein each of the plurality of individual inductive heaters provides an individually controlled heating zone along a longitudinal axis of the gas chromatography column positioned in the apertures of the inductive heaters, each individually controlled heating zone corresponding to a position of a respective inductive element, and wherein a space is present between each inductive element and the gas chromatography column when the gas chromatography column is positioned within the apertures of each inductive element of the plurality of individual inductive heaters. ### Claim 2 (depends on 1) The heater of claim 1, wherein at least one inductive element comprises a planar loop positioned in a radial plane perpendicular to the longitudinal axis of the gas chromatography column positioned in the apertures. ### Claim 3 (depends on 1) The heater of claim 1, wherein each inductive element comprises a planar loop positioned in a radial plane perpendicular to the longitudinal axis of the gas chromatography column positioned in the apertures. ### Claim 4 (depends on 1) The heater of claim 1, wherein at least one inductive element comprises a helix with a radial plane positioned perpendicular to the longitudinal axis of the gas chromatography column positioned in the apertures. ### Claim 5 (depends on 1) The heater of claim 1, wherein at least one inductive element comprises a conical shape with a radial plane positioned perpendicular to the longitudinal axis of the gas chromatography column positioned in the apertures. ### Claim 6 (depends on 1) The heater of claim 1, wherein the plurality of individual inductive heaters comprises at least three individual inductive heaters. ### Claim 7 (depends on 1) The heater of claim 1, wherein the inductive elements of the individual inductive heaters are evenly spaced along the longitudinal axis of the gas chromatography column. ### Claim 8 (depends on 1) The heater of claim 1, wherein each of the inductive elements comprises a similar cross-sectional shape. ### Claim 9 (depends on 1) The heater of claim 1, wherein a cross-sectional shape of a first inductive element is different than a cross-sectional shape of a second inductive element. ### Claim 10 (depends on 1) A gas chromatography system comprising: a column space configured to receive a gas chromatography column; the heater of claim 1; and a detector configured to fluidically couple to the gas chromatography column in the column space. ### Claim 11 (depends on 10) The gas chromatography system of claim 10, wherein at least one inductive element comprises a planar loop in a radial plane perpendicular to the longitudinal axis of the gas chromatography column positioned in the apertures of the plurality of individual inductive heaters. ### Claim 12 (depends on 10) The gas chromatography system of claim 10, wherein each inductive element comprises a planar loop in a radial plane perpendicular to the longitudinal axis of the gas chromatography column positioned in the apertures of the plurality of individual inductive heaters. ### Claim 13 (depends on 10) The gas chromatography system of claim 10, wherein at least one inductive element comprises a helix in a radial plane perpendicular to the longitudinal axis of the gas chromatography column positioned in the apertures of the plurality of individual inductive heaters. ### Claim 14 (depends on 10) The gas chromatography system of claim 10, wherein at least one inductive element comprises a conical shape in a radial plane perpendicular to the longitudinal axis of the gas chromatography column positioned in the apertures of the plurality of individual inductive heaters. ### Claim 15 (depends on 10) The gas chromatography system of claim 10, further comprising a thermally conductive support positioned in the apertures of the plurality of individual inductive heaters, wherein the gas chromatography column is wound around the thermally conductive support to position the longitudinal axis of the gas chromatography column perpendicular to a radial plane of each inductive element of the inductive heaters, and wherein the thermally conductive support is magnetically coupled to each of the inductive elements of the plurality of individual inductive heaters. ### Claim 16 A heater comprising a plurality of inductive heaters, each inductive heater comprising an inductive element and an aperture configured to receive a gas chromatography column, each inductive element comprising a plane being arranged substantially parallel to a plane of each of the other inductive elements, wherein each of the plurality of inductive heaters provides an individually controlled heating zone along a longitudinal axis of the gas chromatography column positioned in the apertures of the inductive heaters, each individually controlled heating zone corresponding to a position of a respective inductive element, the heater further comprising a thermally conductive support positioned in the apertures, wherein the gas chromatography column is wound around the thermally conductive support to position the longitudinal axis of the gas chromatography column perpendicular to a radial plane of each inductive element of the inductive heaters, and wherein the thermally conductive support is magnetically coupled to each of the inductive elements. ### Claim 17 A method of providing a thermal gradient to a gas chromatography column, the method comprising individually controlling a temperature at each of a plurality of heating zones along a longitudinal axis of the gas chromatography column using a plurality of individual inductive heaters, wherein the temperature at each heating zone is controlled using a respective one of the plurality of individual inductive heater, wherein each individual inductive heater comprises an inductive element and an aperture configured to receive the gas chromatography column, wherein a space is present between each inductive element and the gas chromatography column when the gas chromatography column is positioned within the apertures of each inductive element of the plurality of individual inductive heaters, and wherein the temperature at a heating zone at an inlet end of the gas chromatography column is different than a temperature at a heating zone at an exit end of the gas chromatography column to provide the thermal gradient to the gas chromatography column positioned in the apertures of the respective individual inductive heaters. ### Claim 18 (depends on 17) The method of claim 17, wherein the thermal gradient is provided by heating each heating zone along the longitudinal axis of the gas chromatography column, wherein a temperature along the heating zones decreases from the inlet end of the gas chromatography column to the exit end of gas chromatography column. ### Claim 19 (depends on 17) The method of claim 17, wherein the respective individual inductive heaters heat the gas chromatography column and provide the thermal gradient to the gas chromatography column without using an oven. ### Claim 20 (depends on 17) The method of claim 17, further comprising moving at least one of the individual inductive heaters along the longitudinal axis of the positioned gas chromatography column to provide a thermal gradient. ### Claim 21 A method of providing a thermal gradient to a gas chromatography column, the method comprising individually controlling a temperature at each of a plurality of heating zones along a longitudinal axis of the gas chromatography column, wherein the temperature at each heating zone is controlled using a respective inductive heater comprising an inductive element, and wherein the temperature at a heating zone at an inlet end of the gas chromatography column is different than a temperature at a heating zone at an exit end of the gas chromatography column to provide the thermal gradient to the gas chromatography column, wherein the gas chromatography column is wound around a thermally conductive support that is configured to position the longitudinal axis of the gas chromatography column perpendicular to a plane of each inductive element of the inductive heaters, and wherein the thermally conductive support is magnetically coupled to each of the inductive elements.