Targeting peptides for directing adeno-associated viruses (AAVs)
AssigneeCalifornia Institute of Technology
InventorsBenjamin E. Deverman, Viviana Gradinaru, Ken Y. Chan
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Abstract
Disclosed herein are peptide sequences capable of directing adeno-associated viruses (AAV) to target specific environments, for example the nervous system and the heart, in a subject. Also disclosed are AAVs having non-naturally occurring capsid proteins comprising the disclosed peptide sequences, and methods of using the AAVs to treat diseases.
Claims6
A central nervous system (CNS)-targeting adeno-associated virus (AAV) peptide comprising the amino acid sequence of DGTLAVPFKAQ (SEQ ID NO:
- 4).
An adeno-associated virus (AAV) capsid protein comprising a CNS-targeting peptide that comprises the amino acid sequence of DGTLAVPFKAQ (SEQ ID NO:
- 4),
- wherein the amino acid sequence of DGTLAVPFKAQ (SEQ ID NO:
- 4) is inserted between AA586 and AA591 of the AAV capsid protein sequence of SEQ ID NO:
- 45.
Dependencies are inferred from the claim text.