Supramolecular glycosaminoglycans
AssigneeNorthwestern University
InventorsSamuel I. Stupp, Bo Timmy Bjorn Fyrner, Sung Soo Lee
Life of this patent
Estimating the term…
Abstract
Provided herein are glycosylated peptide amphiphiles (GPAs), supramolecular glyconanostructures assembled therefrom, and methods of use thereof. In particular, provided herein are glycosaminoglycan (GAG) mimetic peptide amphiphiles (PAs) and supramolecular GAG mimetic nanostructures assembled therefrom that mimic the biological activities of GAGs, such as heparin, heparan sulfate, hyaluronic acid etc.
Claims11
A composition comprising a supramolecular glyconanostucture, the supramolecular glyconanostucture comprising a nanofiber of glycosylated peptide amphiphiles (GPAs) self-assembled into a nanofiber;
- wherein the GPAs comprise a hydrophobic non-peptide tail, a structured peptide segment, a charged peptide segment, and a terminal saccharide;
- and wherein the nanofiber comprises a hydrophobic core, peptide surface, and saccharides displayed on the surface.
Dependencies are inferred from the claim text.