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US 11,491,227 B2Granted
Cucurbituril-based hydrogels
AssigneeCambridge Enterprise Limited
InventorsOren Scherman, Eric Appel, Xian Jun Loh, Frank Biedermann, Matthew Rowland
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Abstract
The invention provides hydrogel, wherein the hydrogel has a supramolecular cross-linked network obtainable or obtained from the complexation of an aqueous composition including a host, such as cucurbituril, and one or more polymers having suitable guest functionality. One or more polymers in the aqueous composition may have a molecular weight of 50 kDa or more, such as 200 kDa or more. The hydrogel may hold a component, such as a therapeutic compound or a biological molecule. The hydrogels are suitable for use in medicine.
Claims8
A hydrogel having a supramolecular cross-linked network obtainable from the complexation of an aqueous composition comprising a host and one or more polymers having suitable guest functionality,
- wherein the hydrogel holds a component,
- wherein the host is cucurbit[8]uril,
- wherein the one or more polymers have suitable guest functionality,
- wherein the one or more polymers having suitable guest functionality for cucurbit[8]uril have a weight average molecular weight of 50 kDa or more,
- wherein the one or more polymers having suitable guest functionality are hydrophilic,
- wherein the hydrogel has a dominant storage modulus over loss modulus across all strain values in the range 0.1 to 100 rad/s as measured by frequency sweep measurement at 25 degrees centigrade at a strain amplitude of 5 or 10%, and
- wherein the one or more polymers having suitable guest functionality are selected from the group consisting of
- homo polymers of vinyl alcohol,
- hydroxyethyl cellulose,
- homopolymers of vinyl benzene,
- cellulose derivatives,
- hyaluronic acid,
- carboxymethyl cellulose,
- polyacrylamide, and
- homopolymers of vinylbenzyltrimethyl ammonium chloride.
12 more elements
A method for the preparation of a hydrogel holding a component, wherein the method is independently selected from method A or B:
- (A) the method comprising the step of bringing into contact in an aqueous solution a mixture of a host, a component, and one or more polymers having suitable guest functionality, thereby to generate a hydrogel holding a component, wherein the host is a cucurbit[8]uril, and the one or more polymers having suitable guest functionality have suitable guest functionality for cucurbit[8]uril, the one or more polymers having suitable guest functionality have a weight average molecular weight of 50 kDa or more, the one or more polymers having suitable guest functionality are hydrophilic, wherein the hydrogel has a dominant storage modulus over loss modulus across all strain values in the range 0.1 to 100 rad/s as measured by frequency sweep measurement at 25 degrees centigrade at a strain amplitude of 5 or 10%, and the one or more polymers having suitable guest functionality are selected from the group consisting of homopolymers of vinyl alcohol, hydroxyethyl cellulose, homopolymers of vinyl benzene, cellulose derivatives, hyaluronic acid, carboxymethyl cellulose, and homopolymers of vinylbenzyltrimethyl ammonium chloride;
- and
- (B) the method comprising the steps of providing a hydrogel having a supramolecular cross-linked network obtainable from the complexation of an aqueous composition comprising a host and one or more polymers having suitable guest functionality, and agitating that hydrogel in the presence of a component, thereby to incorporate the component into the hydrogel, wherein the host is a cucurbit[8]uril, and the one or more polymers having suitable guest functionality have suitable guest functionality for cucurbit[8]uril, the one or more polymers having suitable guest functionality have a weight average molecular weight of 50 kDa or more, the one or more polymers having suitable guest functionality are hydrophilic, wherein the hydrogel has a dominant storage modulus over loss modulus across all strain values in the range 0.1 to 100 rad/s as measured by frequency sweep measurement at 25 degrees centigrade at a strain amplitude of 5 or 10%, and the one or more polymers having suitable guest functionality are selected from the group consisting of homopolymers of vinyl alcohol, hydroxyethyl cellulose, homopolymers of vinyl benzene, cellulose derivatives, hyaluronic acid, carboxymethyl cellulose, and homopolymers of vinylbenzyltrimethyl ammonium chloride.
A method of delivering a component to a location, the method comprising the steps of:
- (i) providing a hydrogel holding a component, wherein the hydrogel has a supramolecular cross-linked network obtainable from the complexation of an aqueous composition comprising a host and one or more polymers having suitable guest functionality;
- (ii) making the hydrogel available at a target location, wherein the host is a cucurbit[8]uril, and the one or more polymers having suitable guest functionality have suitable guest functionality for cucurbit[8]uril, the one or more polymers having suitable guest functionality have a weight average molecular weight of 50 kDa or more, the one or more polymers having suitable guest functionality are hydrophilic, wherein the hydrogel has a dominant storage modulus over loss modulus across all strain values in the range 0.1 to 100 rad/s as measured by frequency sweep measurement at 25 degrees centigrade at a strain amplitude of 5 or 10%, and the one or more polymers having suitable guest functionality are selected from the group consisting of homopolymers of vinyl alcohol, hydroxyethyl cellulose, homopolymers of vinyl benzene derivatives, cellulose derivatives, hyaluronic acid, carboxymethyl cellulose, and homopolymers of vinylbenzyltrimethyl ammonium chloride;
- and
- (iii) releasing the component from the hydrogel.
1 more element
Dependencies are inferred from the claim text.