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US 11,491,128 B2Granted
Reversible nitroxide derivatives of nitroalkenes that mediate nitrosating and alkylating reactions
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsMarco Fazzari, Bruce A. Freeman, Francisco J. Schopfer
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Abstract
Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating disease. The compositions of such embodiments include reversible nitroxide derivatives of nitroalkenes. The methods of various embodiments include administering an effective amount of any of these pharmaceutical compositions to a patient in need of treatment.
Claims10
A compound of Formula I:
- wherein R1 is —NO2, R2 is —ONO2, X1 is —H;
- and X2 is —COOH;
- and m and n are, independently, an integer from 1 to 10.
Dependencies are inferred from the claim text.