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US 11,485,700 B2Granted
Synthesis of (+)-cannabinoids and their therapeutic effects
AssigneeSymrise AG
InventorsBernd Fiebich, Matthias Winkler, Marcus Rudolf Götz, Oskar Koch
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Abstract
The present invention relates to a method of producing a compound of formula (I) or a salt of a compound of formula (I). The invention also relates to a compound of formula (I) or a salt of a compound of formula (I) for use in a therapeutic method to achieve one or more therapeutic effects as well as for use in the treatment and/or prevention of certain diseases. Furthermore, the invention provides a pharmaceutical composition comprising one or more compound(s) of formula (I) or salt(s) of compound(s) of formula (I).
Claims7
A method for producing a compound of formula (I), or a salt thereof,
- wherein
- X=H or —COOY,
- Y=a saturated or unsaturated, branched or unbranched alkyl group, an aryl group, or a heteroaryl group, having 1 to 12 carbon atoms, respectively, and optionally substituted with one or more amino group(s), hydroxyl group(s) and/or halogen(s), and
- n=2 or 4,
- the method comprising:
- i) reacting 4S-menthadienol in a halogen free solvent with a compound of formula (II) in a continuous flow reaction process,
- wherein n=2 or 4,
- to obtain a compound of formula (III)
- wherein n=2 or 4;
- ii) optionally, transesterification of the compound of formula (III);
- and
- iii) optionally, decarboxylation of the compound of formula (III) and/or the transesterified product of formula (III) with an acid.
9 more elements
Dependencies are inferred from the claim text.