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US 11,485,696 B2Granted
Manufacturing method for high-purity cyclohexenone long-chain alcohol
AssigneeTaiho Pharmaceutical Co., Ltd.
InventorsJian Zhang, Dehui Jiang, Xiaojun Shen
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Abstract
This invention relates to a method for producing a high-purity cyclohexenone long-chain alcohol represented by formula I, and produces the compound of formula I by a metal-mediated Barbier reaction. The method of the present invention has advantages in its short scheme, high yield, and high-purity product, and is suitable for industrial scale up.
Claims15
A method for producing a high-purity cyclohexenone long-chain alcohol represented by formula I, as shown in the following reaction scheme:
- wherein
- R4 represents
- and R5 represents amino;
- the method comprising the steps of
- (1a) subjecting a cyclohexenone long-chain alcohol crude product III and a hydrazine derivative R4NHNH2 to a condensation reaction to obtain a compound II, and
- (1b) hydrolyzing the compound II in the presence of an acidic substance to obtain the high-purity compound I.
3 more elements
Dependencies are inferred from the claim text.