Hemocompatibility of superhemophobic titania surfaces
AssigneeColorado State University Research Foundation
InventorsArun Kumar Kota, Ketul Popat, Sanli Movafaghi, Victoria Leszczak Murphy, Wei Wang
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Abstract
In this work, we investigated the blood platelet adhesion and activation of truly superhemophobic surfaces and compared them with that of hemophobic surfaces and hemophilic surfaces. Our analysis indicates that only those superhemophobic surfaces with a robust Cassie-Baxter state display significantly lower platelet adhesion and activation. The understanding gained through this work will lead to the fabrication of improved hemocompatible, superhemophobic medical implants.
Claims19
A superhemophobic surface comprising:
- nanotubes of fluorine anodized titania, the surface having an arrayed nanotube textured morphology, wherein the anodized titania is annealed and fluorinated with fluorinated (C8-C18)alkyl moieties;
- the nanotubes have a wall thickness of about 20 nm and an opening at the end toward the surface;
- and
- the nanotube textured morphology has a feature diameter (2R) of less than about 1 μm and an inter-feature spacing (2D) of less than about 10 μm.
A superhemophobic surface comprising:
- nanotubes of fluorine anodized titania, the surface having an arrayed nanotube textured morphology, wherein the anodized titania is annealed and fluorinated with fluorinated (C8-C18)alkyl moieties;
- the nanotubes have an opening at the end toward the surface wherein the opening is about 100 nm to about 150 nm wide;
- and
- the nanotube textured morphology has a feature diameter (2R) of less than about 1 μm and an inter-feature spacing (2D) of less than about 10 μm.
Dependencies are inferred from the claim text.