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US 11,484,626 B2Granted
Promoting endothelial cell affinity and antithrombogenicity of polytetrafluoroethylene (PTFE) by mussel-inspired modification and RGD/heparin grafting
AssigneeWisconsin Alumni Research Foundation
InventorsLih-Sheng Turng, Hao-yang Mi
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Abstract
Disclosed herein are methods for modifying a substrate having a hydrophobic surface. Also disclosed are modified hydrophobic substrates. The modified hydrophobic substrates and methods disclosed herein advantageously improve cell affinity and antithrombogenicity of hydrophobic surfaces.
Claims16
A method for modifying a hydrophobic surface, the method comprising:
- treating the hydrophobic surface with oxygen plasma to form an oxygen plasma-treated surface;
- coating the oxygen plasma-treated surface with a solution comprising dopamine to form a dopamine-coated surface;
- coating the dopamine-coated surface with a solution comprising a polymer comprising a terminal amine to form a polymer coating on the dopamine-coated surface;
- and immobilizing a cell adhesion molecule and an anticoagulant on the polymer coating by contacting the cell adhesion molecule and the anticoagulant with the polymer thereby forming a modified hydrophobic surface.
1 more element
A method for modifying a substrate comprising a hydrophobic surface, the method comprising:
- treating the hydrophobic surface with oxygen plasma to form an oxygen plasma-treated surface;
- coating the oxygen plasma-treated surface with a solution comprising dopamine to form a dopamine-coated surface;
- coating the dopamine-coated surface with a solution comprising a polymer comprising a terminal amine to form a polymer coating on the dopamine-coated surface;
- and immobilizing a cell adhesion molecule and an anticoagulant on the polymer coating by contacting the cell adhesion molecule and the anticoagulant with the polymer coating, thereby forming a modified hydrophobic surface on the substrate.
1 more element
A method for modifying a hydrophobic surface, the method comprising:
- treating the hydrophobic surface with oxygen plasma to form an oxygen plasma-treated surface;
- coating the oxygen plasma-treated surface with a solution comprising dopamine to form a dopamine-coated surface;
- coating the dopamine-coated surface with a solution comprising a polymer comprising a terminal amine to form a polymer coating on the dopamine-coated surface;
- and immobilizing a bioactive molecule on the polymer coating by contacting the bioactive molecule with the polymer coating, wherein the hydrophobic surface comprises a vascular graft.
1 more element
Dependencies are inferred from the claim text.