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AssigneesThomas Jefferson University, Icahn School of Medicine at Mount Sinai
InventorsMatthias Schnell, Christine Rettew Fisher, Christoph Wirblich, Gene Tan
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The present disclosure is directed towards chimeric glycoproteins wherein the clip region, a core region, a flap region, and a transmembrane and cytoplasmic domain are defined by starting from the amino terminus of the protein, these domains are comprised of the following amino acid residue ranges: clip, 1 through 40 to 60; core, 40 to 60 through 249 to 281; flap, 249 to 281 through 419 to 459; the transmembrane domain is comprised of amino acids 460 through 480, and the remaining amino acids 481 through 525 comprise the cytoplasmic domain; and wherein the clip, core, flap, transmembrane, and cytoplasmic domain comprise a chimeric combination of at least two lyssavirus, wherein the chimeric glycoprotein is advantageously inserted into a rabies-based vaccine vector.
A chimeric lyssavirus glycoprotein comprising components of both RABV and MOKV glycoproteins within a clip region, a core region, a flap region, and a transmembrane and cytoplasmic domain, wherein the clip region is from a MOKV glycoprotein;
A method of eliciting an immunogenic response to lyssaviruses comprising intramuscular administration of an immunogenic composition containing inactivated chimeric glycoprotein viruses, wherein said inactivated chimeric glycoprotein viruses comprise components of both RABV and MOKV glycoproteins within a clip region, a core region, a flap region, and a transmembrane and cytoplasmic domain, wherein the clip region is from a MOKV glycoprotein, wherein the core region is from a RABV glycoprotein, wherein the flap region is from a MOKV glycoprotein, and wherein the transmembrane and cytoplasmic domain are from a RABV glycoprotein.
A nucleic acid encoding a chimeric G, comprising a clip region, core region, flap region, and a transmembrane and cytoplasmic domain of at least two different lyssaviruses, administered to a patient in its nucleic acid form, wherein the clip region is from a MOKV glycoprotein;
Dependencies are inferred from the claim text.