Bacterial secretome for use in the treatment of skin lesions
AssigneePierre Fabre Dermo-Cosmetique
InventorsNathalie Castex-Rizzi, Marie Florence Galliano, Hélène Hernandez-Pigeon
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Abstract
The present invention relates to a novel use of a bacterial secretome in the field of the treatment of skin lesions and more particularly of wound healing. The invention also relates to cosmetic or dermatological compositions comprising such a bacterial secretome as active agent.
Claims13
A method of treatment of skin lesions which comprises administering to a patient in need thereof a bacterial secretome of a non-pathogenic Gram-negative bacterium belonging to the class Betaproteobacteria, subfamily Neisseriaceae, wherein the bacterium is the bacterium deposited with the CNCM on 8 Apr. 2010 under number 14920, and
- said secretome is obtained by a process comprising the steps of:
- a) culturing said bacterium in a culture medium and under conditions suitable for its growth,
- b) liquid/solid separation of the culture medium and recovery of the liquid phase,
- c) adding a basic buffer to the liquid phase obtained in step b) and incubating the buffered liquid phase obtained for 1 to 7 hours, optionally at a temperature between 1 and 6° C., and
- d) obtaining said secretome comprising biomolecules secreted by said bacterium in the liquid phase.
A method of treatment of skin lesions which comprises administering to a patient in need thereof a dermatological composition comprising a bacterial secretome of a non-pathogenic Gram-negative bacterium belonging to the class Betaproteobacteria, subfamily Neisseriaceae, a copper salt and/or a zinc salt and a suitable dermatological excipient, wherein
- the bacterium is the bacterium deposited with the CNCM on 8 Apr. 2010 under number 14920, and
- said secretome is obtained by a process comprising the steps of:
- a) culturing said bacterium in a culture medium and under conditions suitable for its growth,
- b) liquid/solid separation of the culture medium and recovery of the liquid phase,
- c) adding a basic buffer to the liquid phase obtained in step b) and incubating the buffered liquid phase obtained for 1 to 7 hours, optionally at a temperature between 1 and 6° C., and
- d) obtaining said secretome comprising biomolecules secreted by said bacterium in the liquid phase.
Dependencies are inferred from the claim text.