Antisense nucleic acid for inhibiting biosynthesis of chondroitin sulfate
AssigneesAichi Medical University, National Institutes of Biomedical Innovation, Health and Nutrition
InventorsSatoshi Obika, Yuya Kasahara, Kosei Takeuchi
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Abstract
The present invention provides an antisense oligonucleotide for inhibiting biosynthesis of chondroitin sulfate. The antisense oligonucleotide comprises at least one modified nucleotide, wherein the antisense oligonucleotide suppresses expression of one or both of the chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT1) gene and the chondroitin sulfate N-acetylgalactosaminyltransferase-2 (CSGalNAcT2) gene.
Claims15
An antisense oligonucleotide comprising at least one modified nucleotide, wherein the antisense oligonucleotide suppresses expression of one or both of the chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT1) gene and the chondroitin sulfate N-acetylgalactosaminyltransferase-2 (CSGalNAcT2) gene, wherein the antisense oligonucleotide consists of the nucleotide sequence set forth in SEQ ID NO:
- 113.
A method for treating a disease or a condition related to an increase in chondroitin sulfate, comprising administering to a subject an antisense oligonucleotide comprising at least one modified nucleotide, wherein the antisense oligonucleotide consists of a nucleotide sequence of SEQ ID NO:
- 113.
Dependencies are inferred from the claim text.