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US 11,479,755 B2Granted
T cell compositions
Assignee2seventy bio, Inc.
InventorKevin Friedman
Life of this patent
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Abstract
The invention provides improved T cell compositions and methods for manufacturing T cells. More particularly, the invention provides methods of T cell manufacturing that result in adoptive T cell immunotherapies with improved survival, expansion, and persistence in vivo.
Claims19
A method for manufacturing chimeric antigen receptor (CAR) T cells comprising:
- (a) activating a population of T cells and stimulating the population of T cells to proliferate;
- (b) transducing the T cells with a viral vector comprising a polynucleotide encoding a CAR;
- (c) culturing the transduced T cells to proliferate;
- wherein steps a)-c) are performed in the presence of a phosphatidylinositol-3 kinase (PI3K) inhibitor, and wherein the PI3K inhibitor is a small organic molecule.
1 more element
Dependencies are inferred from the claim text.