Deoxyuridine triphosphatase inhibitors

A compound of Formula (I):

• or a tautomer thereof, or a deuterium isotope of each of the above wherein up to 10 hydrogen atoms that are attached to one or more carbon atoms are replaced with deuterium(s), or a pharmaceutically acceptable salt of each of the foregoing, or a pharmaceutically acceptable solvate of each of the above mentioned,
• wherein
• A is
• L1 is an optionally substituted C3-C10 alkylene, further wherein at least two geminal hydrogens together with the carbon to which they are attached are optionally replaced with cyclopropano or cyclobutano;
• optionally substituted C3-C10 alkenylene, optionally substituted C3-C10 heteroalkylene, optionally substituted C3-C10 heteroalkenylene, or -L11-L12-L13-, wherein L11 is attached to A and L11 is O, S, NR, C1-C2 alkylene, C2 alkenylene, C2 heteroalkylene, or C3 heteroalkenylene, L12 is arylene or heteroarylene, L13 is a bond or an optionally substituted C1-C5 alkylene, and R is H or C1-C3 alkyl;
• L2 is —SO2NR50—, wherein the sulfur is attached to L1;
• or —NR50SO2—, wherein the nitrogen is attached to L1;
• each R50 independently is hydrogen, an optionally substituted C1-C6 alkyl, an optionally substituted C2-C6 heteroalkyl, an optionally substituted C2-C6 alkenyl, an optionally substituted C3-C6 heteroalkenyl, an optionally substituted C2-C6 alkynyl, an optionally substituted C3-C6 heteroalkynyl, or Z;
• Z is
• each R51 and R52 independently is hydrogen or an optionally substituted C1-C10 alkyl;
• X is an optionally substituted hydroxy group, an optionally substituted NH2 group, or an optionally substituted SH group;
• L3 is an optionally substituted C1-C6 alkylene, an optionally substituted C2-C6 heteroalkylene, an optionally substituted C2-C6 alkenylene, an optionally substituted C3-C6 heteroalkenylene, an optionally substituted C2-C6 alkynylene, or an optionally substituted C3-C6 heteroalkynylene;
• and
• B is
• each R1-R3 independently is H, F, Cl, C1-C3 alkyl, or OR20;
• R20 is CH2-R21;
• methyl optionally substituted with 2 or 3 fluorine atoms;
• C3-C6 cycloalkyl;
• or C1-C6 alkyl;
• and
• R21 is C1-C10 alkyl optionally substituted with one or more hydroxy or fluoro;
• or C3-C6 cycloalkyl;
• or
• wherein each R22-R24 independently is an optionally substituted C1-C3 alkyl or hydroxy.