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US 11,478,550 B2Granted
Biodegradable hydrogel and methods for use thereof
AssigneesInternational Business Machines Corporation, Institute of Bioengineering and Nanotechnology
InventorsMareva B. Fevre, James L. Hedrick, Ashlynn Lee, Nathaniel H. Park, Rudy J. Wojtecki, Yi Yan Yang, Zhi Xiang Voo
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Abstract
The subject matter of this invention relates to hydrogel compositions and, more particularly, to hydrogel compositions comprising block copolymers (BCPs) capable of self-assembly into nanoparticles for the delivery and controlled release of therapeutic cargos.
Claims10
A hydrogel composition comprising:
- a first ABA triblock copolymer having negatively charged A blocks, wherein the first ABA triblock copolymer is a phenylboronic acid-functionalized polycarbonate/poly(ethylene glycol) (PEG) ABA triblock copolymer;
- and
- a second ABA triblock copolymer having positively charged A blocks.
A micellar particle comprising:
- a hydrogel composition comprising:
- a first ABA triblock copolymer having negatively charged A blocks, wherein the first ABA triblock copolymer is a phenylboronic acid-functionalized polycarbonate/poly(ethylene glycol) (PEG) ABA triblock copolymer;
- and
- a second ABA triblock copolymer having positively charged A blocks;
- and
- at least one agent for delivery within the hydrogel composition.
3 more elements
Dependencies are inferred from the claim text.