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US 11,478,544 B2Granted
Chimeric hepatitis D virus antigen and hepatitis B virus pre S1 genes for use alone or in vaccines contaning hepatitis B virus genes
AssigneeSvenska Vaccinfabriken Produktion AB
InventorsMatti Sällberg, Lars Frelin
Life of this patent
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Abstract
Chimeric genes, compositions of chimeric genes, and compositions of polypeptides that are useful for the generation, enhancement, or improvement of an immune response to a target antigen. Some embodiments of the compositions include chimeric genes encoding hepatitis D antigen (HDAg) protein in combination with one or more self-cleavage 2A polypeptides and a preS1 polypeptide. In certain embodiments the self-cleavage polypeptide is P2A.
Claims14
A chimeric gene comprising at least two Hepatitis D Antigen (HDAg) sequences, the chimeric gene comprising:
- a nucleic acid construct encoding at least two HDAg antigen sequences selected from the group consisting of HDAg genotype 1A, HDAg genotype 1 B, HDAg genotype 2A and HDAg genotype 2B;
- at least one cleavage sequence;
- and at least one sequence encoding a pre-S 1 domain of a surface antigen of a hepatitis B virus.
Dependencies are inferred from the claim text.