Glaucoma treatment
AssigneesThe Research Foundation for The State University of New York, Icahn School of Medicine at Mount Sinai
InventorsIoannis Danias, Oscar A. Candia, Rosana Gerometta
Life of this patent
Estimating the term…
Abstract
Disclosed herein are methods of treatment for an intraocular pressure (IOP)-associated condition in a subject, that include administering to the subject an effective amount of a tissue plasminogen activator (tPA) therapeutic agent. In one embodiment, the IOP-associated condition is glaucoma. The administration of a tPA therapeutic agent can be an extended administration intended to cause a reduction in IOP in the subject for a period of at least one day to a year or more, relative to IOP levels in the subject prior to administration of the tPA therapeutic agent. The tPA therapeutic agent can be, for example, tPA, a tPA derivative, a small molecule direct or indirect tPA agonist, or a gene therapy vector.
Claims14
A method of treatment for a chronic intraocular pressure (IOP)-associated condition in a subject, the method comprising:
- administration to the subject of an effective amount of a tissue plasminogen activator (tPA) therapeutic agent, wherein the tPA therapeutic agent is:
- a tPA gene therapy vector, comprising a nucleic acid sequence encoding:
- tPA;
- a tPA variant, functional derivative or homolog or a protein that causes up-regulation of tPA or a ribonucleic acid (RNA) molecule that causes down-regulation of a negative regulator of tPA expression or activity.
A method of increasing outflow facility in a subject, the method comprising:
- administration to the subject of an effective amount of a tissue plasminogen activator (tPA) therapeutic agent, wherein the tPA therapeutic agent is:
- a tPA gene therapy vector, comprising a nucleic acid sequence encoding:
- tPA;
- a tPA variant, functional derivative or homolog or a protein that causes up-regulation of tPA or a ribonucleic acid (RNA) molecule that causes down-regulation of a negative regulator of tPA expression or activity.
Dependencies are inferred from the claim text.