Recombinant Corynebacterium having 1,3-PDO productivity and reduced 3-HP productivity, and method for producing 1,3-PDO by using same
AssigneesKorea Advanced Institute of Science and Technology, Hanwha Solutions Corporation
InventorsSang Yup Lee, Jae Sung Cho, Je Woong Kim, Cindy Pricilia Surya Prabowo, Taehee Han, Yoo Sung Ko
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Abstract
The present invention relates to recombinant Corynebacterium having 1,3-PDO productivity and reduced 3-HP productivity, and a method for producing 1,3-PDO by using same. When a Corynebacterium glutamicum variant according to the present invention is used, the productivity of 3-HP, which is a by-product, is inhibited by using low-cost glycerol as a carbon source, and thus 1,3-PDO can be produced with high efficiency.
Claims3
A mutant Corynebacterium glutamicum cell that has been genetically modified by (i) introducing the E. coli glpF gene, the E. coli glpK gene, the E. coli glpD gene, the E. coli yqhD gene, and the K. pneumoniae pduCDEG operon, and (ii) disrupting an endogenous gene encoding an aldehyde dehydrogenase that comprises comprising a nucleotide sequence selected from the group consisting of SEQ ID NO:
- 56, 57, 59, 60, 61, 62, 63, 65, 66, 67, and 68.
Dependencies are inferred from the claim text.