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US 11,473,110 B2Granted
Xylitol producing Metschnikowia species
AssigneeCreatus Biosciences Inc.
InventorsZongli Luo, Hendrik Jurgens Jansen Van Vuuren, Allan George DeBono, Andrew Taplin Ferguson
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Abstract
Provided herein are Metschnikowia species that produce xylitol from xylose when cultured, as well as methods to make and use these Metschnikowia species.
Claims19
A culture medium comprising xylose, an isolated Metschnikowia species and bioderived xylitol produced by the isolated Metschnikowia species, wherein the isolated Metschnikowia species comprises:
- (a) at least one exogenous nucleic acid encoding a xylose reductase or that results in overexpression of a xylose reductase of the isolated Metschnikowia species;
- and (b) a genetic modification that attenuates or inactivates a xylitol dehydrogenase of the isolated Metschnikowia species, wherein the isolated Metschnikowia species is the Metschnikowia species designated Accession No. 081116-01, deposited at the International Depositary Authority of Canada, an International Depositary Authority, on Nov. 8, 2016, under the terms of the Budapest Treaty.
Dependencies are inferred from the claim text.