Redox dehydration coupling catalysts and methods related thereto
AssigneeEmory University
InventorsLanny Steven Liebeskind, Pavan Kumar Reddy Gangireddy
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Abstract
This disclosure relates to synthetic coupling methods using catalytic molecules. In certain embodiments, the catalytic molecules comprise heterocyclic thiolamide, S-acylthiosalicylamide, disulfide, selenium containing heterocycle, diselenide compound, ditelluride compound or tellurium containing heterocycle. Catalytic molecules disclosed herein are useful as catalysts in the transformation of hydroxy group containing compounds to amides, esters, ketones, and other carbon to heteroatom or carbon to carbon transformations
Claims2
A method of catalyzing a coupling reaction comprising mixing
- a) a compound comprising a hydroxy group as a segment of a carboxylic acid group,
- b) a PR3, wherein PR3 is a trisubstituted phosphite, phosphine or a phosphorus containing five member heterocycle,
- c) an amine nucleophile, and
- d) a catalytic heterocycle which is 5-nitro-2-(2-(pyridin-2-yl) propan-2-yl)benzo[d]isothiazol-3(2H)-one:
- under conditions such that an amide compound is formed comprising the amine in place of the hydroxy group.
Dependencies are inferred from the claim text.