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US 11,471,581 B2Granted
Acoustophoresis device having improved dimensions
AssigneeThe Charles Stark Draper Laboratory, Inc.
InventorsJason Fiering, Ryan Silva, Parker Stewart Dow
Life of this patent
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Abstract
Systems and methods for cleansing blood are disclosed herein. The methods include acoustically separating target particles from elements of whole blood. The whole blood and capture particles are flowed through a microfluidic separation channel formed in a thermoplastic. At least one bulk acoustic transducer is attached to the microfluidic separation channel. A standing acoustic wave, imparted on the channel and its contents by the bulk acoustic transducer, drives the formed elements of the blood and target particles to specific aggregation axes.
Claims20
A system, comprising:
- a separation channel within a first thermoplastic substrate defined by a first wall, a second wall, and a roof, the first thermoplastic substrate coupled to a second thermoplastic substrate forming a floor of the separation channel, the floor configured to couple with an acoustic transducer oscillating at a selected frequency;
- wherein:
- a first width of the separation channel is selected to be between 0.15 and 5 times an acoustic wavelength of an acoustic wave imparted in a fluid by the acoustic transducer at the selected frequency;
- a second width of each of the first wall and the second wall is selected based at least on the first width of the separation channel and a velocity of the acoustic wave in at least one of the first wall or the second wall;
- one or more inlets defined within the first thermoplastic substrate to introduce the fluid into a proximal end portion of the separation channel;
- and
- one or more outlets of the first thermoplastic substrate positioned at a downstream portion of the separation channel.
4 more elements
A device, comprising:
- an acoustic transducer,
- a separation channel within a first thermoplastic substrate defined by a first wall, a second wall, and a roof, the first thermoplastic substrate coupled to a second thermoplastic substrate forming a floor of the separation channel, the floor configured to couple with the acoustic transducer oscillating at a selected frequency;
- wherein:
- a first ratio of a width of the separation channel to a height of the separation channel is selected to be between 2 and 3.5;
- a second ratio of a thickness of the floor of the separation channel to the width of the separation channel is selected to be between 0.2 and 1.5;
- and
- one or more inlets defined within the first thermoplastic substrate to introduce a fluid into a proximal end portion of the separation channel;
- and
- one or more outlets of the first thermoplastic substrate positioned at a downstream portion of the separation channel.
6 more elements
A method to process fluid, comprising
- providing a device comprising an acoustic transducer and:
- a separation channel within a first thermoplastic substrate defined by a first wall, a second wall, and a roof, the first thermoplastic substrate coupled to a second thermoplastic substrate forming a floor of the separation channel, the floor configured to couple with the acoustic transducer oscillating at a selected frequency,
- wherein:
- a first width of the separation channel is selected to be between 0.15 and 5 times an acoustic wavelength of an acoustic wave imparted in a fluid by the acoustic transducer at the selected frequency, and
- a second width of each of the first wall and the second wall is selected based at least on the first width of the separation channel and a velocity of the acoustic wave in at least one of the first wall or the second wall, and
- one or more inlets defined within the first thermoplastic substrate to introduce the fluid into a proximal end portion of the separation channel;
- and
- one or more outlets of the first thermoplastic substrate positioned at a downstream portion of the separation channel;
- and
- flowing a target fluid through an inlet, wherein the target fluid comprises target particles;
- and
- driving, with the acoustic wave generated by the acoustic transducer, the target particles toward one of the first wall or the second wall of the separation channel.
9 more elements
Dependencies are inferred from the claim text.