Methods for treatment of H. pylori infections
AssigneesMax-Planck-Gesellschaft zur Forderung, Der Wissenschaft En E.V., Technische Universität München
InventorsAnahita Javaheri, Tobias Kruse, Markus Gerhard, Bernhard B. Singer, Daniel Hornburg, Han Remaut, Matthias Mann, Felix Meissner, Steffen Backert
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Abstract
The present invention relates to inhibitors of the interaction between H. pylori IIopQ and a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as well as to immunogenic compositions based on H. pylori HopQ. The present invention further relates to the use of the inhibitors and immunogenic compositions for preventing or treating a disease or disorder caused by or associated with H. pylori.
Claims6
A method of treating a disease or disorder caused by or associated with H. pylori, the method comprising the step of administering an inhibitor of an interaction between Helicobacter pylori HopQ and a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family,
- wherein the inhibitor is selected from the group consisting of
- (a) (poly-)peptide ligands binding to an extracellular domain of H. pylori HopQ;
- and
- (b) nucleic acid molecules encoding the (poly-)peptide ligands of (a);
- wherein the extracellular domain of H. pylori HopQ is the insertion domain, loop A, loop B, loop C or loop D of H. pylori HopQ, wherein
- loop A is located between helix H3 and strand S1 of H. pylori HopQ;
- loop B is located between strand S2 and helix H4 of H. pylori HopQ;
- loop C is located between helix H5 and helix H6 of H. pylori HopQ;
- and
- loop D is located between helix H7 and helix H8 of H. pylori HopQ,
- wherein the inhibitor inhibits binding of H. pylori HopQ to an extracellular domain of the member of the CEACAM family, and/or
- wherein the inhibitor inhibits binding to the N-domain of the member of the CEACAM family.
Dependencies are inferred from the claim text.