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US 11,471,517 B2Granted
Compositions and methods for preventing and treating graft versus host disease
AssigneesThe University of North Carolina at Chapel Hill, Regents of the University of Minnesota
InventorsJonathan Serody, James Coghill, Danny Bruce, Bruce Blazar, Heather Stefanski, Benjamin Vincent
Life of this patent
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Abstract
ILC2 cells play a role in the pathogenesis of graft versus host disease (GvHD) and idiopathic pneumonia syndrome (IPS), both conditions associated with allogeneic stem cell transplantation. Infusion of IL-33 activated ILC2 cells into patients with ongoing GvHD or IPS, or prior to onset of GvHD or IPS in susceptible patients, substantially ameliorates the disease and improves survival.
Claims8
A method for treating acute graft versus host disease (GvHD) in a subject, comprising:
- providing a subject in need of treatment for acute GvHD;
- and
- administering to the subject a therapeutically effective amount of a cell preparation of IL-33 activated ILC2 cells.
Dependencies are inferred from the claim text.