Autophagy modulators for use in treating cancer
AssigneeThe United States of Americans represented by the Secretary, Department of Health and Human Services
InventorsMelvin L. DePamphilis, Gaurav Sharma, Juan Jose Marugan, Marc Ferrer, Ajit Roy
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Abstract
Disclosed is method for treating cancer in a mammal, comprising administering to a mammal in need thereof a compound of the formula: wherein R1, R2, and R3 are as defined herein, wherein the cancer is an autophagy-dependent cancer, in an amount sufficient to induce autophagy in the cell and cause the death of cancer cells. Also disclosed is a method for selectively killing cancer cells in a patient afflicted with cancer, comprising administering to the mammal, wherein the cancer cells are autophagy-dependent cancer cells, in an amount sufficient to induce autophagy in the cells and cause the death of the cancer cells.
Claims8
A method of (a) treating cancer in a mammal, wherein the cancer is an autophagy-dependent cancer or (b) selectively killing cancer cells in a mammal afflicted with cancer, wherein the cancer cells are autophagy-dependent cancer cells, comprising administering to the mammal an effective amount of a compound selected from:
- or a pharmaceutically acceptable salt thereof;
- wherein the method selectively inhibits PIKFYVE (phosphoinositide kinase FYVE-type zinc finger containing).
Dependencies are inferred from the claim text.