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US 11,471,414 B2Granted
Compositions and methods for the treatment and prophylaxis of surgical site infections
AssigneePolypid Ltd.
InventorNoam Emanuel
Life of this patent
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Abstract
The present invention provides methods for preventing, inhibiting or treating a surgical site infection associated with a surgical operation comprising the step of applying to the surgical site a biocompatible, biodegradable substrate being impregnated and/or having its surface coated fully or partially with a matrix composition which provides local controlled and prolonged release of at least one pharmaceutically active agent at the surgical site.
Claims22
A method for treatment or prophylaxis of a soft-tissue incision site infection associated with a surgical operation, wherein the method comprises:
- administering directly to the soft-tissue incision site, a biodegradable mineral substrate shaped in the form of particles,
- wherein the mineral substrate is impregnated or has its surface coated fully or partially with a matrix composition,
- wherein the matrix composition comprises:
- (a) a biodegradable polyester;
- (b) a first lipid component comprising at least one sterol, wherein the at least one sterol is non-covalently associated with the biodegradable polyester;
- (c) a second lipid component comprising at least one phospholipid having fatty acid moieties of at least 12 carbons;
- and
- (d) an antibiotic agent selected from the group consisting of:
- doxycycline and doxycycline hyclate.
6 more elements
Dependencies are inferred from the claim text.