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US 11,467,161 B2Granted
Biomarkers of therapeutic responsiveness
AssigneeMeso Scale Technologies, LLC.
InventorsSimone Barbero, Eli N. Glezer, Anu Mathew, Mingyue Wang
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Abstract
The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
Claims13
A method of administering a treatment regimen to a patient in need thereof for treating renal cell carcinoma (RCC), wherein said treatment regimen is sunitinib, said method comprising:
- (a) measuring a baseline level of at least one biomarker in a test sample obtained from said patient before undergoing said treatment regimen, wherein the at least one biomarker is SFRP-1 and measuring an interim level of the at least one biomarker in a test sample obtained from the patient after undergoing said treatment regimen;
- (b) comparing said baseline level of said at least one biomarker to the interim level of said at least one biomarker;
- and
- (c) continuing administration of said treatment regimen to said patient when in step (b) said interim level of SFRP-1 is higher than the baseline level.
1 more element
Dependencies are inferred from the claim text.