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US 11,466,300 B2Granted
Method for producing N-Acetyl-D-Glucosamine and/or D-Glucosamine salt by microbial fermentation
OwnerLan Suninventor
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Abstract
This Invention discloses a method for production of N-Acetyl-D-Glucosamine and/or D-Glucosamine Salt by microbial fermentation. The method is intended to manufacture N-Acetyl-D-Glucosamine and/or D-Glucosamine Salt in higher efficiency and higher yield, by increasing the effects of N-Acetyl-D-Mannosamine Kinase.
Claims12
A method for production of N-Acetyl-D-Glucosamine and/or D-Glucosamine by microbial fermentation, comprising:
- A) Cultivating of a microorganism in a fermentation medium, where the said microorganism contains at least one genetic modification that may increase the effects of N-Acetyl-D-Mannosamine Kinase in microorganism;
- and
- B) Collecting N-Acetyl-D-Glucosamine produced in the step A);
- wherein the said genetic modification contains substitutions at the following corresponding sites of SEQ ID NO:
- 17:
- substitution of glutamine at Site 36 by arginine, substitution of isoleucine at Site 103 by methionine, and substitution of arginine at Site 223 by serine.
3 more elements
Dependencies are inferred from the claim text.