Method for preparing a non-radioactive standard β-CFT
AssigneeInstitute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.O.C.
InventorsChing Yun Lee, Yu Chang
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Abstract
This invention discloses method for preparing a non-radioactive standard β-CFT. Using cocaine hydrochloride as the starting material, and after a series of hydrolysis, dehydration, esterification and bonding reactions, a non-radioactive standard (2β-Carbomethoxy-3β-(4-fluoropenyl) tropane) is prepared. Furthermore, this preparation method has fewer steps, is easy to operate, and the purity of the product is as high as 97.97%. Therefore, the method for preparing a non-radioactive standard β-CFT can promote the development of positron imaging in the diagnosis of Parkinson's disease.
Claims6
A preparing method of non-radioactive standard β-CFT, the steps include:
- Taking a cocaine hydrochloride and a hydrochloric acid for a hydrolysis reaction to form an ecgonine hydrochloride;
- Taking the ecgonine hydrochloride and a phosphorus oxychloride for a dehydration reaction to form a (R)-(-)-Anhydroecgonine methyl ester;
- and
- And taking the (R)-(-)-Anhydroecgonine methyl ester and a Grignard reagent making a bonding reaction to form a 2β-Carbomethoxy-3β-(4-fluoropenyl) tropane.
Dependencies are inferred from the claim text.