Anthranilic amides and the use thereof
AssigneesThe Administrators of the Tulane Educational Fund, Duquesne University of the Holy Ghost
InventorsSuravi Chakrabarty, Patrick T. Flaherty, Darlene Monlish, Jane E. Cavanaugh, Matthew E. Burow, Steven Elliott, Van T. Hoang
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Abstract
Disclosed are anthranilic amide derivatives having the formula. Compositions are disclosed that include the anthranilic amide derivatives and the use of the anthranilic amide derivatives for the manufacture of a medicament. Further disclosed are methods of inhibiting or treating cancer, inhibiting or reversing an epithelial to mesenchymal cellular transition, and/or inhibiting MEK1/2 and/or MEK 5 enzymatic activity in a subject by administering to the subject an effective amount of a disclosed anthranilic amide derivative.
Claims5
A compound of formula:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.