Bismuth-thiol compositions and methods of use
AssigneeMicrobion Corporation
InventorsBrett Hugh James Baker, Jeffrey W. Millard
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Abstract
The invention relates to Bis-thiol compounds and pharmaceutical preparations thereof. The invention further relates to methods of treating, managing or lessening the severity of pulmonary infections in a subject, the method comprising administering to the subject a bismuth-thiol (BT) composition that comprises at least one BT compound.
Claims22
A method of treating, managing or lessening the severity of cystic fibrosis (CF) symptoms and infections in a subject, the method comprising administering to the subject an aerosol comprising a plurality of dispersed liquid droplets, wherein the liquid droplets comprise a bismuth-thiol (BT) composition that comprises bismuth-1,2-ethanedithiol (BisEDT) microparticles suspended therein, the BisEDT microparticles having a D90 of less than about 2 μm as measured by laser diffraction, and wherein at least 70% of the liquid droplets have a mass median aerodynamic diameter (MMAD) from about 0.4 μm to about 5 μm as measured by cascade impaction or laser time of flight.
A method of treating, managing or lessening the severity of symptoms and infections associated with one or more pulmonary diseases or infections in a subject, the method comprising administering to the subject an aerosol comprising a plurality of dispersed liquid droplets, wherein the liquid droplets comprise a bismuth-thiol (BT) composition that comprises BisEDT microparticles suspended therein, the BisEDT microparticles having a D90 of less than about 2 μm as measured by laser diffraction, and wherein at least 70% of the liquid droplets have a MMAD from about 0.4 μm to about 5 μm as measured by cascade impaction or laser time of flight.
Dependencies are inferred from the claim text.