TRPA1 activity inhibitor
AssigneesMandom Corporation, Takasago International Corporation
InventorsMasayuki Takaishi, Fumitaka Fujita, Hironori Shimizu, Shu Sakuyama, Kenya Ishida, Kenji Maruyama
Life of this patent
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Abstract
This TRPA1 activity inhibitor contains a compound represented by formula (I) wherein R1, R2, R3 and R4 each independently represent a hydrogen atom or a methyl group, and R5, R6, R7 and R8 each independently represent a hydrogen atom, a methyl group or —O—R9—OH (in the formula, R9 represents an alkylene group optionally having a substituent group), provided that at least one group of R5, R6, R7 and R8 is —O—R9—OH.
Claims8
A composition, comprising a TRPA1 agonist and a therapeutically effective amount for inhibiting TRPA1 activity induced by the TRPA1 agonist of a compound represented by formula (I):
- wherein each of R1, R2, R3 and R4 is independently a hydrogen atom or a methyl group, each of R5, R6, R7 and R8 is independently a hydrogen atom, a methyl group or a group represented by formula (II):
- —O—R9—OH (II)
- wherein R9 is an alkylene group which may have a substituent;
- with the proviso that at least one group of R5, R6, R7 and R8 is a group represented by the formula (II), and
- wherein the therapeutically effective amount of the compound represented by the formula (I) is able to inhibit the TRPA1 activity induced by the TRPA1 agonist.
A method for inhibiting TRPA1 activity, comprising a step of applying a compound in a presence of a TRPA1 agonist to a skin which needs the inhibition of the TRPA1 activity induced by the TRPA1 agonist, thereby contacting a TRPA1 -expressing cell in the skin with the compound, wherein the compound is represented by formula (I):
- wherein each of R1, R2, R3 and R4 is independently hydrogen atom or methyl group, each of R5, R6, R7 and R8 is independently a hydrogen atom, a methyl group or a group represented by formula (II):
- —O—R9—OH (II)
- wherein R9 is an alkylene group which may have a substituent;
- with the proviso that at least one group of R5, R6, R7 and R8 is a group represented by the formula (II), and
- wherein the TRPA1 activity is exhibited by binding the TRPA1 agonist to TRPA1, thereby activating the TRPA1.
Dependencies are inferred from the claim text.