Microbial fermentation for the production of terpenes
AssigneeLanzaTech NZ, Inc.
InventorMichael Koepke
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Abstract
The invention provides a method for producing a terpene or a precursor thereof by microbial fermentation. Typically, the method involves culturing a recombinant bacterium in the presence of a gaseous substrate whereby the bacterium produces a terpene or a precursor thereof, such as mevalonic acid, isopentenyl pyrophosphate, dimethylallyl pyrophosphate, isoprene, geranyl pyrophosphate, farnesyl pyrophosphate, and/or farnesene. The bacterium may comprise one or more exogenous enzymes, such as enzymes in mevalonate, DXS, or terpene biosynthesis pathways.
Claims30
A recombinant C1-fixing microorganism capable of producing mevalonic acid, or a terpene precursor, from a carbon source comprising a nucleic acid encoding a group of exogenous enzymes comprising thiolase, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase, and HMG-CoA reductase, wherein the microorganism is from Clostridium or Moorella.
Dependencies are inferred from the claim text.