Loading patent…
AssigneeWuhan Neurophth Biotechnology Limited Company
InventorBin Li
Estimating the term…
A gene sequence of recombinant human type II mitochondrial dynein-like GTPase having a nucleotide sequence shown in SEQ ID NO: 1 and uses thereof. A fusion nucleic acid comprising a nucleic acid encoding human type II mitochondrial dynein-like GTPase. A recombinant expression vector comprising the nucleic acid or a fusion nucleic acid. A transformant by which the nucleic acid or the fusion nucleic acid is introduced into a host. A non-human mammalian ADOA model based on the inactivation of the gene of type II mitochondrial dynein-like GTPase, which can effectively improve the pathological manifestations of ADOA using a recombinant expression vector encoding the human type II mitochondrial dynein-like GTPase. The expression level of the nucleic acid encoding the human type II mitochondrial dynein-like GTPase is higher, therefore, more human type II mitochondrial dynein-like GTPase can be obtained in the mitochondria. which can better treat eye diseases such as ADOA.
A recombinant nucleic acid, comprising a nucleotide sequence that encodes a human type II mitochondrial dynein-like GTPase, and wherein the nucleotide sequence is ≥95% identical to the sequence of SEQ ID NO:
A method for increasing the expression and/or activity of a mitochondrial dynein-like GTPase in a cell, comprising:
A method for treating an eye disease, comprising:
A method for preparing a recombinant nucleic acid, comprising culturing a host cell comprising the recombinant nucleic acid, wherein the recombinant nucleic acid comprises a nucleotide sequence that encodes a human type II mitochondrial dynein-like GTPase, and wherein the nucleotide sequence is ≥95% identical to the sequence of SEQ ID NO:
Dependencies are inferred from the claim text.