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US 11,459,293 B2Granted
Compositions and methods of making expanded hematopoietic stem cells using derivatives of fluorene
AssigneeImmuneBridge Inc.
InventorsJesse Cotari, Timothy Webb, Zhan Wang
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Abstract
This invention is directed to, inter alia, compounds, methods, systems, and compositions for the maintenance, enhancement, and expansion of hematopoietic stem cells derived from one or more sources of CD34+ cells. Sources of CD34+ cells include bone marrow, cord blood, mobilized peripheral blood, and non-mobilized peripheral blood. Also provided herein are compounds of Formula I which are useful in maintaining, enhancing, and expanding of hematopoietic stem cells.
Claims14
A compound of Formula IIIa1
- or a pharmaceutically acceptable salt, hydrate, or solvate thereof;
- wherein,
- R1 is —NH—C(O)—R1a NRb—C(O)—R1a,
- R1a is selected from the group consisting of C2-6 alkyl and C2-6 haloalkyl;
- R2 is —OH;
- and
- the subscript n is 0 or 1.
4 more elements
Dependencies are inferred from the claim text.