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US 11,459,288 B2Granted
Process for preparing azelaic acid
AssigneeCorum Inc.
InventorNai-Hsuan Hsu
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Abstract
A process for preparing azelaic acid is disclosed. In particular, the process for preparing azelaic acid is an ozone free process. The process for preparing azelaic acid comprises a step of decarboxylation of tetra-carboxylic acid in the presence of a organic sulfonic acid.
Claims6
A process for preparing azelaic acid, comprising:
- i. reacting malonontrile with a pentane having two leaving groups bound to 1 and 5 carbon in the presence of a base to form a 1,7 tetra-substituted heptane as shown in formula (C);
- where R2 is —CN;
- ii. hydrolyzing the 1,7 tetra-substituted heptane in acidic condition to form a tetra-carboxylic acid as shown in formula (D);
- and
- iii. performing decarboxylation of the tetra-carboxylic acid in the presence of an organic sulfonic acid to form azelaic acid.
2 more elements
Dependencies are inferred from the claim text.