Pharmaceutical composition comprising erythrocytes encapsulating a PLP-dependent enzyme and, a non-phosphate PLP precursor
AssigneeErytech Pharma
InventorsYann Godfrin, Vanessa Bourgeaux, Fabien Gay, Thomas Cortese
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Abstract
The invention relates to a pharmaceutical composition containing a PLP-dependent enzyme and optionally its cofactor, pyridoxal phosphate (PLP), and/or a phosphate or non-phosphate precursor of PLP, its use as a drug, its production method and a therapeutic treatment method related to it. The pharmaceutical composition comprises erythrocytes and a pharmaceutically acceptable vehicle, the erythrocytes encapsulating the PLP-dependent enzyme. The PLP-dependent enzyme may be methioninase, tyrosine phenol-lyase, tyrosine aminotransferase or cystathionine beta-synthase.
Claims19
One or more erythrocyte(s) encapsulating a plurality of pyridoxal phosphate (PLP)-dependent enzyme molecules, the erythrocytes comprising a sufficient amount of pyridoxine kinase (PN-kinase) and pyridoxine phosphate oxidase (PNP oxidase) to produce a sufficient amount of PLP from PLP precursor present in a subject's bloodstream to maintain a sufficient portion of the erythrocyte-encapsulated PLP-dependent enzyme molecules in their holoenzyme forms to preserve enzymatic activity beyond 24 hours after injection or infusion into the subject in need of said enzymatic activity.
Dependencies are inferred from the claim text.