Materials and methods for assessing cancer risk and treating cancer
AssigneeThe Johns Hopkins University
InventorsAmi A. Shah, Livia Casciola-Rosen, Antony Rosen, Takeru Igusa, Marikki K. Laiho
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Abstract
This document relates to materials and methods for assessing and/or treating subjects (e.g., subjects having autoimmune diseases). For example, materials and methods for determining if a subject (e.g., a human having an autoimmune disease) has one or more antibodies that can be used to identify the subject as having a lower risk of cancer or as having a higher risk of cancer are provided. Materials and methods for treating a subject (e.g., a human) identified as having a higher cancer risk for cancer are also provided.
Claims4
A method for treating cancer in a subject having an autoimmune disease comprising:
- identifying the subject as having cancer cells;
- and
- administering to the subject:
- (i) an anti-RNA polymerase Ill antibody or antibody fragment, and
- (ii) an anti-RPA194 antibody or antibody fragment;
- wherein the number of cancer cells within the subject is reduced;
- and
- wherein the autoimmune disease is selected from the group consisting of:
- scleroderma, systemic lupus erythematosus, and myositis.
Dependencies are inferred from the claim text.