On-surface mass tagging
AssigneeNortheastern University
InventorsPushkar Kulkarni, Poguang Wang, Roger W. Giese
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Abstract
The present disclosure relates to a method for detecting a compound, comprising the steps of: contacting a compound with a solid analytical surface (SAS), thereby forming an SAS with an absorbed compound; contacting the SAS with the absorbed compound with a mass tag, wherein the mass tag reacts with the absorbed compound, thereby forming an SAS with a covalently mass-tagged absorbed compound; and detecting the covalently mass-tagged absorbed compound by mass spectrometry. Also disclosed is a device for collecting breath aerosol, comprising a card or an envelope, wherein the card or the envelope comprise a tab, wherein the tab is a SAS.
Claims12
A method for detecting a compound, comprising the steps of:
- contacting a compound with a solid analytical surface (SAS), thereby forming a SAS with an absorbed compound;
- contacting the SAS with the absorbed compound with a mass tag, wherein the mass tag reacts with the absorbed compound, thereby forming a SAS with a covalently mass-tagged absorbed compound;
- and
- detecting the covalently mass-tagged absorbed compound by mass spectrometry;
- wherein
- the mass tag is
Dependencies are inferred from the claim text.