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US 11,454,626 B2Granted
Single-cell imaging mass spectrometry
AssigneeEuropean Molecular Biology Laboratory
InventorsTheodore Alexandrov, Luca Rappez
Life of this patent
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Abstract
The present invention relates to a method for single-cell imaging mass spectrometry (MS) by correlating an optical image of a cell sample with an MS image. The method of the invention is in particular useful in research to test concomitantly optical and molecular phenotypes at a single-cell resolution.
Claims20
A method of single cell(s) mass spectrometry (MS) imaging, the method comprising the steps of
- (a) Culturing cell(s) on a substrate,
- (b) phenotyping the cell(s) by microscopy to obtain at least one optical image showing an optical phenotype of the cell(s),
- (c) phenotyping of the cell(s) by imaging MS to obtain an MS molecular image showing a molecular phenotype of the cell(s),
- (d) Comparing the optical image and the MS molecular image to at least one of:
- compare, correlate, and assign, the optical phenotype of at least one single cell with the corresponding molecular phenotype of at least one single cell,
- wherein steps (b) and (c) are performed in any order/sequence.
3 more elements
Dependencies are inferred from the claim text.