Method and apparatus for non-invasively measuring circulatory hemoglobin

A method of non-invasively determining a blood circulatory hemoglobin value for a subject using a near-infrared spectrophotometric (NIRS) sensing device, comprising:

• non-invasively sensing tissue of the subject using the NIRS sensing device at about a time T1, and determining at least one T1 NIRS tissue totalHb value based on the non-invasive sensing at about the time T1, and non-invasively sensing tissue of the subject using the NIRS sensing device at about a time T2, which time T2 is different than time T1, and determining at least one T2 NIRS tissue totalHb value based on the non-invasive sensing at about the time T2;
• acquiring at least one circulatory blood sample from the subject at about the time T1, and acquiring at least one circulatory blood sample from the subject at about the time T2;
• determining at least one T1 blood circulatory THb value of the circulatory blood sample acquired at the time T1, and determining at least one T2 blood circulatory THb value of the circulatory blood sample acquired at the time T2;
• calibrating the NIRS sensing device using the at least one T1 blood circulatory THb value, the at least one T1 NIRS tissue totalHb value, the at least one T2 blood circulatory THb value, and the at least one T2 NIRS tissue totalHb value;
• and
• determining at least one blood circulatory hemoglobin value using the calibrated NIRS sensing device and at least one subsequent NIRS tissue totalHb value.

A near-infrared spectrophotometric (NIRS) sensing device configured to non-invasively determine a blood circulatory hemoglobin value for a subject, comprising:

• at least one transducer portion having at least one light source and a least one light detector;
• a processor portion in communication with the at least one transducer portion, the processor portion including at least one processor in communication with stored instructions, which instructions when executed cause the processor to:
• control the at least one transducer portion to non-invasively sense tissue of the subject using the NIRS sensing device at about a time T1, and determine at least one NIRS tissue totalHb value based on the non-invasive sensing;
• calibrate the NIRS sensing device using the at least one NIRS tissue TotalHb value, and at least one blood circulatory THb value of a circulatory blood sample acquired at about the time T1;
• and
• determine at least one blood circulatory hemoglobin value using the calibrated NIRS sensing device and at least one subsequent NIRS tissue totalHb value.

A near-infrared spectrophotometric (NIRS) sensing device configured to non-invasively determine a blood circulatory hemoglobin value for a subject, comprising:

• at least one transducer portion having at least one light source and a least one light detector;
• a processor portion in communication with the at least one transducer portion, the processor portion including at least one processor in communication with stored instructions, which instructions when executed cause the processor to:
• control the at least one transducer portion to non-invasively sense tissue of the subject using the NIRS sensing device at about a time T1, and determine at least one T1 NIRS tissue totalHb value based on the non-invasive sensing at about the time T1, and to non-invasively sense tissue of the subject using the NIRS sensing device at about a time T2, which time T2 is different than time T1, and to determine at least one T2 NIRS tissue totalHb value based on the non-invasive sensing at about the time T2;
• calibrate the NIRS sensing device using the at least one T1 NIRS tissue TotalHb value, at least one T1 blood circulatory THb value of a circulatory blood sample acquired at about the time T1, the at least one T2 NIRS tissue TotalHb value, at least one T2 blood circulatory THb value of a circulatory blood sample acquired at about the time T2;
• and
• determine at least one blood circulatory hemoglobin value using the calibrated NIRS sensing device and at least one subsequent NIRS tissue totalHb value.