Chimeric decoy

A double-stranded oligonucleotide decoy showing binding affinities for two transcription factors, comprising a first binding site for a first transcription factor and a second binding site for a second transcription factor,

• wherein a first strand comprising the sense strand of said first binding site and a second strand comprising the sense strand of said second binding site are hybridized to form a double strand in which said sense strand of the first binding site and said sense strand of the second binding site are at least partly hybridized,
• wherein said decoy has a size of 13 mer to 15 mer, and
• wherein at least a part of bonds between each nucleotide in the double-stranded oligonucleotide constituting the decoy includes a phosphorothioate bond.

A double-stranded oligonucleotide decoy showing binding affinities for two transcription factors, comprising a first binding site for a first transcription factor and a second binding site for a second transcription factor,

• wherein a first strand comprising the sense strand of said first binding site and a second strand comprising the sense strand of said second binding site are hybridized to form a double strand in which said sense strand of the first binding site and said sense strand of the second binding site are at least partly hybridized,
• wherein said decoy has a size of 13 mer to 15 mer, and
• wherein the decoy has a 5′ end, and wherein the 5′ end of the decoy is bound, via a linker or directly, to a polylactic acid/glycolic acid copolymer (PLGA) nanoparticle.