Antibodies that bind IL-4 and/or IL-13 and their uses
AssigneeSanofi
InventorsErcole Rao, Vincent Mikol, Danxi Li, Jochen Kruip, Matthew Davison
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel humanized anti-IL-4 and IL-13 antibodies and fragments thereof and novel bispecific antibodies and fragments thereof that specifically bind to IL-4 and IL-13. The invention also includes uses of the antibodies to treat or prevent IL-4 and/or IL-13 mediated diseases or disorders, including allergic asthma and dermatitis.
Claims12
An isolated humanized antibody or antibody fragment thereof that specifically binds IL-13, wherein the antibody or antibody fragment thereof comprises a light chain variable domain comprising CDRs having the amino acid sequences RASESVDSYGQSYMH (SEQ ID NO:
- 8), LASNLES (SEQ ID NO:
- 9), and QQNAEDSRT (SEQ ID NO:
- 10) and a heavy chain variable domain comprising CDRs having the amino acid sequences GFSLTDSSIN (SEQ ID NO:
- 11), DGRID (SEQ ID NO:
- 12), and DGYFPYAMDF (SEQ ID NO:
- 13).
Dependencies are inferred from the claim text.