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US 11,453,723 B1Granted
BCMA T cell-antigen couplers and uses thereof
AssigneeMcMaster University
InventorsJonathan Lorne Bramson, Joanne Alicia Hammill, Christopher W. Helsen
Life of this patent
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Abstract
BCMA T cell antigen coupler (TAC) polypeptides having (i) an antigen-binding domain that binds BCMA, (ii) an antigen-binding domain that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide are provided.
Claims15
A polynucleotide encoding a BCMA (B Cell Maturation Antigen) T cell-antigen coupler (BCMA-TAC) polypeptide, comprising the sequence set forth in SEQ ID NO:
- 68, SEQ ID NO:
- 70, SEQ ID NO:
- 72, or SEQ ID NO:
- 74.
1 more element
A BCMA (B Cell Maturation Antigen) T cell-antigen coupler (BCMA-TAC) polypeptide, comprising the sequence set forth in SEQ ID NO:
- 67, SEQ ID NO:
- 69, SEQ ID NO:
- 71, or SEQ ID NO:
- 73.
1 more element
Dependencies are inferred from the claim text.