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US 11,453,722 B2Granted
Bispecific antigen binding molecule for a costimulatory TNF receptor
AssigneeHoffmann-La Roche Inc.
InventorsMaria Amann, Sandra Grau-Richards, Christian Klein, Mudita Pincha, Pablo Umaña
Life of this patent
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Abstract
The invention relates to novel bispecific antigen binding molecules comprising (a) at least one moiety capable of specific binding to OX40, and (b) at least one moiety capable of specific binding to tenascin C (TnC), and to methods of producing these molecules and to methods of using the same.
Claims13
A bispecific antigen binding molecule, comprising
- (a) at least one moiety capable of specific binding to OX40 comprising an antibody light chain variable region (VL) comprising the amino acid sequence of SEQ ID NO:28 and an antibody heavy chain variable region (VH) comprising the amino acid sequence of SEQ ID NO:27, and
- (b) at least one moiety capable of specific binding to tenascin C (TnC) comprising (i) a VH comprising the amino acid sequence of SEQ ID NO:52 and a VL comprising the amino acid sequence of SEQ ID NO:53, or (ii) a VH comprising the amino acid sequence of SEQ ID NO:54 and a VL comprising the amino acid sequence of SEQ ID NO:55, connected to the C-terminus of the Fc region, and
- (c) an Fc region composed of a first and a second subunit capable of stable association, wherein the Fc region is of human IgG1 subclass with the amino acid mutations L234A, L235A and P329G (numbering according to Kabat EU index).
A bispecific antigen binding molecule, selected from the group consisting of
- (i) a bispecific antigen binding molecule comprising two heavy chains, each comprising the amino acid sequence of SEQ ID NO:213, two light chains, each comprising the amino acid sequence of SEQ ID NO:212, and two light chains, each comprising the amino acid sequence of SEQ ID NO:214,
- (ii) a bispecific antigen binding molecule comprising two heavy chains, each comprising the amino acid sequence of SEQ ID NO:215, two light chains, each comprising the amino acid sequence of SEQ ID NO:212, and two light chains, each comprising the amino acid sequence of SEQ ID NO:216,
- (iii) a bispecific antigen binding molecule comprising a first heavy chain comprising the amino acid sequence of SEQ ID NO:222, a second heavy chain comprising the amino acid sequence of SEQ ID NO:223, and four light chains, each comprising the amino acid sequence of SEQ ID NO:212, and
- (iv) a bispecific antigen binding molecule comprising two heavy chains, each comprising the amino acid sequence of SEQ ID NO:225, four light chains, each comprising the amino acid sequence of SEQ ID NO:224, and two light chains, each comprising the amino acid sequence of SEQ ID NO:226.
1 more element
Dependencies are inferred from the claim text.