Back to results
US 11,453,718 B2Granted
NOTCH3 agonist compositions and methods for treating small vessel diseases
AssigneeThe Schepens Eye Research Institute, Inc.
InventorJoseph F. Arboleda-Velasquez
Life of this patent
Estimating the term…
Abstract
The present subject matter provides, inter alia compositions, formulations, and methods for inhibiting, treating, and preventing small vessel diseases.
Claims9
A method for treating a small vessel disease (SVD) in a subject, comprising administering to the subject an effective amount of a Neurogenic Locus Notch Homolog Protein 3 (NOTCH3) agonist, wherein the NOTCH3 agonist comprises a polypeptide comprising a JAGGED1 extracellular domain or fragment thereof that comprises a stretch of amino acids having the sequence set forth in SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.