Trispecific antibodies against IL-17A, IL-17F and other pro-inflammatory molecule

A tri-specific binding molecule comprising a first binding domain that binds to human IL-17A and human IL-17-F and a second binding domain that binds to human TNFα, wherein said first binding domain comprises H-CDR1, H-CDR2, H-CDR3 sequences:

• a) wherein H-CDR1 comprises an amino acid sequence corresponding to SEQ ID NO:
• 1, H-CDR2 comprises an amino acid sequence corresponding to SEQ ID NO:
• 2 and H-CDR3 comprises an amino acid sequence corresponding to SEQ ID NO:
• 3;
• or
• b) a variant of a), comprising one amino acid substitution selected from the group consisting of:
• the amino acid at the 6th position of SEQ ID NO:
• 1 is S, N, K, R, E, W, M, Q, D, F, V L or A;
• the amino acid at the 7th position of SEQ ID NO:
• 1 is P or S;
• the amino acid at the 8th position of SEQ ID NO:
• 1 is M or I;
• the amino acid at the 9th position of SEQ ID NO:
• 1 is G, L, A, I, S, R, V, N, Q or M;
• the amino acid at the 1st position of SEQ ID NO:
• 2 is A, G or L;
• the amino acid at the 4th position of SEQ ID NO:
• 2 is P or A;
• the amino acid at the 7th position of SEQ ID NO:
• 2 is G, S, R, P, D, I, T, E, K, A or L;
• the amino acid at the 1st position of SEQ ID NO:
• 3 is V, S, T, A, K, D or G;
• the amino acid at the 2nd position of SEQ ID NO:
• 3 is R or K;
• the amino acid at the 3rd position of SEQ ID NO:
• 3 is R, Y, H, W, K, D or G;
• the amino acid at the 4th position of SEQ ID NO:
• 3 is R, A, L, M, S, H or V;
• the amino acid at the 6th position of SEQ ID NO:
• 3 is D, E, G, A, R, V, K or Q;
• the amino acid at the 7th position of SEQ ID NO:
• 3 is G, N or S;
• the amino acid at the 8th position of SEQ ID NO:
• 3 is T, G, P, V, R, S, N or K;
• the amino acid at the 9th position of SEQ ID NO:
• 3 is S, V, M, T, L, T, A, H, G, I or C;
• the amino acid at the 10th position of SEQ ID NO:
• 3 is Y, W or S;
• the amino acid at the 11th position of SEQ ID NO:
• 3 is Y, R, L, W, K, A, G, Q, I or V;
• and
• the amino acid at the 12th position of SEQ ID NO:
• 3 is T, A, L or S;
• said second binding domain comprises a heavy chain comprising H-CDR1, H-CDR2, H-CDR3 sequences, wherein H-CDR1 comprises an amino acid sequence corresponding to SEQ ID NO:
• 10, H-CDR2 comprises an amino acid sequence corresponding to SEQ ID NO:
• 11 and H-CDR3 comprises an amino acid sequence corresponding to of SEQ ID NO:
• 12;
• and
• a light chain comprising L-CDR1, L-CDR2, L-CDR3 sequences, wherein L-CDR1 comprises an amino acid sequence corresponding to SEQ ID NO:
• 13, L-CDR2 comprises an amino acid sequence corresponding to SEQ ID NO:
• 14 and L-CDR3 comprises an amino acid sequence corresponding to SEQ ID NO:
• 15.